The annonalide diterpene extracted from Casimirella ampla (Miers) reduces inflammatory and antinociceptive events in general models of inflammation.

ETHNOPHARMACOLOGICAL RELEVANCE: The plants of the genus Casimirella ampla (Miers) (C. ampla) are extensively used in folk medicine. For a long time, rural communities have been using extracts from its roots for food and therapeutic purposes. The extract is rich in diterpenoid annonalide (Annona), which has antiophidic, anti-inflammatory and antinociceptive properties. Inflammation is the body's primary defense mechanism against cell damage and invasion by pathogens, which can trigger acute and chronic inflammatory processes. The first line of treatment for this condition consists of the use of non-steroidal anti-inflammatory drugs, but these have numerous associated collateral damages, based on scientific knowledge about diterpenoids from C. ampla, as well as their already reported antinociceptive and anti-inflammatory properties. AIMS OF THE STUDY: Evaluate the effect of Annona in classic models of inflammation and pain. MATERIALS AND METHODS: Animals were pretreated with Annona (0.1, 1.0 and 10 mg/kg), or Tween 80 (2%), or indomethacin (Indo) (10 mg/kg) orally in the paw edema tests induced by carrageenan (Cg), serotonin (5-HT), histamine, bradykinin, 48/80 and, prostaglandin E2 (PGE2), evaluating microscopic lesion scores, migration of leukocytes to the peritoneal cavity, concentration of myeloperoxide (MPO), malonyldialdehyde (MDA) and glutathione (GSH), abdominal contortion test by acetic acid and formalin test. RESULTS: Treatment with Annona compound at a dose of 0.1 mg/kg was more effective in reducing inflammatory, oxidant and nociceptive parameters, as it reduced paw edema induced by carrageenan, through different mediators and migration of inflammatory cells. Furthermore, it worked by reducing the concentration of MPO, MDA, preserving GSH levels and reducing nociception caused by formalin and acetic acid.

Cuidado à saúde da pessoa em situação de rua: debate e relatos para uma abordagem intersetorial / Health care of the homeless: debate and reports for an intersectorial approach

Este artigo apresenta relato referente ao "I Encontro sobre as Políticas de Atendimento à População em Situação de Rua: Articulação entre SUS e SUAS", realizado por residentes da Residência Multiprofissional em Saúde da Família em Parnaíba (PI) durante os meses de outubro e novembro de 2016. O objetivo é discorrer sobre o encontro e discutir as políticas de atendimento à pessoa em situação de rua - PSR. O evento teve como público-alvo os agentes comunitários de saúde (ACS) e enfermeiros de quatro Distritos de Saúde. O evento possibilitou a discussão sobre a PSR, as políticas de reconhecimento dessa população, a existência e qualidade do serviço ofertado pelo Centro de Referência Especializado para População de Rua e a discussão de casos. Desse modo, o evento proporcionou aos profissionais de saúde a oportunidade de lançar um novo olhar em relação à PSR e criou a possibilidade de realização de outros eventos com o mesmo tema destinado aos profissionais de outros setores da rede.

This paper presents a report about the "I Conference on Policies for Assistance to Homeless People: Articulation between SUS and SUAS", held on October 2016 by a team of residents of the Multi-professional Residence in Family Health in Parnaíba city, Brazil, from October to November 2016. This study aims to discuss the Conference and the assistance policies for homeless people. The conference's audience was the Health Community Agents (HCA) and nurses from 4 Health Districts. The event allowed discussions about homeless people, recognition policies of this population, existence and quality of the service offered by the Specialized Reference Centre for the Homeless People and case discussions. Thus, the health professionals on Conference had the opportunity to take a fresh look towards the homeless people and raised the possibility of the realization of other events with the same subject intended to professionals from other sectors of the network.